The 1933 Centre Colonels football team represented Centre College as a member of the Dixie Conference and the Southern Intercollegiate Athletic Association (SIAA) in the 1933 college football season. Led by fifth-year head coach Ed Kubale, the Colonels compiled an overall record of 7–3 and with a mark of 2–0 in Dixie Conference play and 3–1 against SIAA competition. The team played home games at Cheek Field in Danville, Kentucky.
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