Van Sant or van 't Sant or van't Sant is a surname, and may refer to:
François van 't Sant (1883–1966), Dutch head-commissioner of police Gus Van Sant (born 1952), American film director and musician John Van Sant (1915–1972), American politician from Pennsylvania Joshua Van Sant (1803–1884), U.S. Representative and Mayor of Baltimore (1871–1875) Mike Van Sant, American drag racer Onno Hattinga van't Sant (born 3 May 1946), Dutch diplomat Peter Van Sant (born 1953), American reporter Samuel Rinnah Van Sant (1844–1936), Governor of Minnesota (1901–1905) Tom Van Sant (1931–2023), American artist
See also Sant (surname)