Gasco is a Puerto Rican surname. Notable people with the surname include:
Dario Alejandro Gasco (born 1987), Argentine professional mountain biker Elyse Gasco (born 1967), Canadian fiction writer Ernesto Gasco (born 1963), Spanish politician Vincent Gasco (1907–1961), Spanish footballer Walter López Gasco (born 1985), Uruguayan footballer
See also Gasco (disambiguation) Agustín García-Gasco Vicente (1931–2011), Spanish Cardinal of the Catholic Church Tina Gascó (1914–1973), Spanish actress Garcia Moniz, o Gasco, medieval Knight