Pixley is a surname, and may refer to:
Andrew Pixley (1943–1965), American convicted murderer Annie Pixley (c.1848–1893), American stage actress Charles C. Pixley (1923–2005), Surgeon General of the United States Army Francis W. Pixley (c.1852–1933), English accountant, barrister and author Frank M. Pixley (1825–1895), American journalist, attorney and politician Frank S. Pixley (c.1867–1919), American educator, newspaper editor, playwright and lyricist George V. Pixley (1937–2023), American Christian theologian Gus Pixley (1873–1923), American actor, singer and comic Lloyd Pixley (c.1900−1954), American football player Ray Pixley (1907–1936), American racing driver