Methyl-TMA, or N-methyl-TMA, also known as N-methyl-3,4,5-trimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and 3C families. "Three additional N-methylated homologues of known psychedelics warrant mention, but do not really deserve separate recipes. This is because they have had only the most cursory assaying, which I have learned about by personal correspondence. [...] METHYL-TMA [...] had been run up in several trials to a maximum of 240 [mg], with some mental disturbances mentioned only at this highest level. METHYL-TMA-2 [...] had been tried at up to 120 [mg] without any effects. METHYL-TMA-6 [...] had been tried at up to 30 [mg] and it, too, was apparently without effects. These are reports that I have heard from others, but I have had no personal experience with them. Those that I can describe from personal experience are entered separately as recipes of their own. And there are many, many other N-methyl homologues which have been prepared and characterized in the literature, and have yet to be tasted. So far, however, the only consistent thing seen is that, with N-methylation, the potency of the psychedelics is decreased, but the potency of the stimulants appears to be pretty much maintained." It is the N-methyl derivative of 3,4,5-trimethoxyamphetamine (TMA) as well as the α,N-dimethyl derivative of mescaline (3,4,5-trimethoxyphenethylamine).
Use and effects N-Methylation of psychedelic phenethylamines has invariably greatly reduced or eliminated their hallucinogenic activity. Examples of this include related compounds like Beatrice (N-methyl-DOM) and methyl-DOB (N-methyl-DOB), which at assessed doses appear to be inactive as psychedelics in humans. According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) however, methyl-TMA showed "some mental disturbances" at the highest assessed dose of 240mg orally. For comparison, the active dose range of TMA is 100 to 250mg orally.
Interactions
History Methyl-TMA was first described in the scientific literature by at least 1984. It was subsequently described further by Shulgin in PiHKAL in 1991.
Society and culture Legal status Canada Methyl-TMA is a controlled substance in Canada under phenethylamine blanket-ban language.
See also 3C (psychedelics) N-Methylmescaline Trichocereine (N,N-dimethylmescaline) Beatrice (N-methyl-DOM) N-Methyl-DOET N-Methyl-DOB N-Methyl-TMA-2 Methyl-DMA (N-methyl-2,5-DMA)
References
External links METHYL-TMA - Isomer Design