Simcoe is a surname, and may refer to:
Anthony Simcoe (born 1969), Australian actor Elizabeth Simcoe (1762–1850), British artist and diarist, wife of John Graves Simcoe John Graves Simcoe (1752–1806), British army officer, the first lieutenant governor of Upper Canada Michael Simcoe (born c.1960), Australian automobile designer Robert A. Simcoe (born 1975), American astrophysicist at MIT William Simcoe, American politician from Maryland of the 1840s