The 2006 Samford Bulldogs football team represented Samford University as a member of the Ohio Valley Conference (OVC) during the 2006 NCAA Division I FCS football season. Led by sixth-year head coach Bill Gray, the Bulldogs compiled an overall record of 3–8, with a mark of 1–7 in conference play, and finished eighth in the OVC. The team played home games at Seibert Stadium in Homewood, Alabama.
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