The 2005 Samford Bulldogs football team represented Samford University as a member of the Ohio Valley Conference (OVC) during the 2005 NCAA Division I-AA football season. Led by fifth-year head coach Bill Gray, the Bulldogs compiled an overall record of 5–6, with a mark of 4–4 in conference play, and finished tied for fourth in the OVC. The team played home games at Seibert Stadium in Homewood, Alabama.
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