Lumi-LSD, also known as 10-hydroxy-9,10-dihydro-LSD or as N,N-diethyl-9,10-dihydro-10-hydroxylysergamide, is a lysergamide and chemical degradation product of the psychedelic drug lysergic acid diethylamide (LSD). LSD is converted into lumi-LSD by exposure to light, specifically ultraviolet light. "A second and separate point of instability is the double bond that lies between this 8-position and the aromatic ring. Water or alcohol can add to this site, especially in the presence of light (sunlight with its ultraviolet energy is notoriously bad) to form a product that has been called lumi-LSD, which is totally inactive in man." Lumi-LSD might also be a metabolite of LSD, but this remains unconfirmed.
Pharmacology Pharmacodynamics Lumi-LSD showed 0.01% (i.e., 10,000-fold lower) of the antiserotonergic activity of LSD in the isolated rat uterus in vitro. As such, lumi-LSD was regarded as essentially inactive in this assay. Similarly, lumi-LSD shows abolished physiological and behavioral effects in animals and is said to be inactive in terms of hallucinogenic effects in humans. Likewise, in contrast to LSD, lumi-LSD was found to be inactive in terms of electroencephalogram (EEG) changes in rabbits.
Chemistry Unlike LSD, lumi-LSD is not fluorescent.
Other lumi-lysergamides are also known.
History
Lumi-LSD was first described in the scientific literature by at least 1955.
See also Substituted lysergamide 9,10-Dihydro-LSD Iso-LSD
References
External links Lumi-LSD - Isomer Design