The 2024–25 Coupe de France preliminary rounds, Grand Est was the qualifying competition to decide which teams from the leagues of the Grand Est region of France took part in the main competition from the seventh round.
A total of twenty teams qualified from the Grand Est preliminary rounds.
In the 2023–24 edition of the competition, US Thionville Lusitanos and Sarreguemines FC both progressed furthest, reaching the round of 64 stage. Thionville were defeated by Ligue 1 side Olympique de Marseille by a single goal, whilst Sarreguemines succumbed to Ligue 2 side FC Valenciennes in a two-goal defeat.
Draws and Fixtures On 18 July 2024, the league published the draw for the first round of the competition. The draw consisted of 360 ties featuring teams from district divisions and some from the third tier of the regional league. The draw also listed the 213 clubs still exempt at this stage, confirming that 933 from the region were taking part in the competition this season. The second round draw was published on 20 August 2024, and saw the remaining teams from the third tier of the regional league, and all but four teams from the second tier of the regional league, join the competition. The third round draw, which say the entry of all remaining teams from the regional league, the seven teams from Championnat National 3, and the qualifying team from Saint Pierre and Miquelon, was published on 3 September 2024.
The fourth round draw, which saw the five teams from Championnat National 2 enter the competition, was published in three parts (with reference to the three geographical sectors the league splits itself into) on 17 and 18 September 2024. The fifth round draw was published on 1 October 2024, and saw the single Championnat National team from the region enter the competition. The sixth round draw was published on 17 October 2024.
First round These matches were played on 15, 16, 17, 18 and 21 August 2024.