The 2024–25 Coupe de France preliminary rounds, Pays de la Loire was the qualifying competition to decide which teams from the leagues of the Pays de la Loire region of France took part in the main competition from the seventh round.
A total of eleven teams qualified from the Pays de la Loire preliminary rounds.
In 2023–24, FC Challans and Les Herbiers VF both progressed to the Round of 64, before losing to higher tier opposition at home. Challans were defeated 4–0 by Ligue 2 side Rodez AF, whilst Les Herbiers were knocked out on penalties by Championnat National side LB Châteauroux on penalties, after a 2–2 draw.
Draws and fixtures The Pays de la Loire league published the first round draw on 2 August 2024. Three days later, they published the full structure of the competition, confirming a total of 516 teams from the region had entered, and that 414 teams would take part in the first round, including all teams from the District levels and all but 29 teams from the Régional 3 division. The second round would include the remainder of the Régional 3 teams and 40 teams from Régional 2. The third round would include 17 teams from Régional 1 and 7 teams from Championnat National 3. The 5 teams from Championnat National 2 would enter at the fourth round stage, and the sole team from Championnat National would enter at the fifth round stage.
The second round draw was published on 28 August 2024. The third round draw was published on 12 September 2024. The fourth round draw took place on 18 September 2024, with the results published on 20 September 2024. The fifth round draw took place on 2 October 2024, with the results published a day later. The sixth round draw was made live on the league's official Facebook page on 16 October 2024.
First round These matches were played on 25 August 2024.