Since the foundation of the Southern League in 1964 its pitchers have thrown 101 no-hitters, which include four perfect games. Of these no-hitters, 52 were pitched in games that lasted at least the full nine innings, while 49 were pitched in games shortened due to weather or that were played in doubleheaders, which are typically seven innings. Only two of the league's four perfect games were tossed in full nine-inning games. Thirty no-hitters were combined—thrown by two or more pitchers on the same team.

A no-hit game occurs when a pitcher (or pitchers) allows no hits during the entire course of a game. A batter may still reach base via a walk, an error, a fielder's choice, a hit by pitch, a passed ball or wild pitch on strike three, or catcher's interference. Due to these methods of reaching base, it is possible for a team to score runs without getting any hits. While the vast majority of no-hitters are shutouts, teams which went hitless have managed to score runs in their respective games nine times in Southern League games, some in extra innings.

The first Southern League no-hitter was thrown on May 3, 1964, by Doug Gallagher of the Knoxville Smokies against the Asheville Tourists at Bill Meyer Stadium in Knoxville, Tennessee, as part of a seven-inning doubleheader. The first nine-inning feat occurred on August 11, 1965, when Bill Whitby of the Charlotte Hornets no-hit Asheville at Clark Griffith Park in Charlotte, North Carolina. The first perfect game was pitched on July 6, 1967, by George Lauzerique of the Birmingham A's against the Evansville White Sox at Bosse Field in Evansville, Indiana, as part of a seven-inning doubleheader. The first nine-inning perfect game occurred on August 14, 1970, when Charles Swanson of the Montgomery Rebels accomplished the feat against the Savannah Indians at Grayson Stadium in Savannah, Georgia.

Five league pitchers have participated in multiple Southern League no-hitters. Jimmie Brown, who pitched two for the Montgomery Rebels in 1968, is the only pitcher with two solo no-hit games. Griffin Canning (both in 2018), Ryan Clark (both in 2018), Ryan Franklin (both in 1997), and Eric Torres (2022 and 2023) have each participated in two combined no-hitters. Franklin's were made in back-to-back starts with the Memphis Chicks, with the second being a solo affair. Canning and Clark were the starting and closing pitchers, respectively, for the same no-hit games with the Mobile BayBears.

The team with the most no-hitters is the Knoxville Smokies, with 11. They are followed by the Birmingham Barons (9 no-hitters, 1 a perfect game) and the Jacksonville Suns (9 no-hitters). Four teams (Birmingham, the Montgomery Rebels, Orlando Rays, and Pensacola Blue Wahoos) have each thrown one perfect game.

No-hitters +KeyGame score with no-hitter team's runs listed firstStadium in italics denotes a no-hitter thrown in a home game.A number following a score indicates number of innings in a game that was shorter or longer than 9 innings.A number following a pitcher's name indicates multiple no-hitters thrown.Innings pitchedIndicates a perfect game

+No-hittersDatePitcher(s)TeamScoreOpponentLocation1Knoxville Smokies3–0 Asheville TouristsBill Meyer Stadium2Birmingham Barons2–0 Chattanooga LookoutsEngel Stadium3Columbus Confederate Yankees2–0 Charlotte HornetsClark Griffith Park4Charlotte Hornets5–0Asheville TouristsClark Griffith Park5Columbus Confederate Yankees2–0 Lynchburg White SoxGolden Park6Evansville White Sox1–0 Columbus Confederate YankeesGolden Park7Macon Peaches0–0 Evansville White SoxLuther Williams Field8Birmingham A's1–0 Evansville White SoxBosse Field9Montgomery Rebels2–0Birmingham A'sPaterson Field10Birmingham A's2–0 Evansville White SoxRickwood Field11 Montgomery Rebels2–0 Charlotte HornetsClark Griffith Park12 Montgomery Rebels3–0Birmingham A'sPaterson Field13Columbus White Sox3–0 Montgomery RebelsPaterson Field14Montgomery Rebels6–0 Savannah SenatorsPaterson Field15Asheville Tourists3–0 Savannah SenatorsGrayson Stadium16Montgomery Rebels3–0Savannah IndiansPaterson Field17Jacksonville Suns3–0Montgomery RebelsWolfson Park18Asheville Tourists1–0 Savannah BravesGrayson Stadium19Columbus Astros2–0Charlotte HornetsClark Griffith Park20Columbus Astros3–0Jacksonville SunsWolfson Park21Savannah Braves1–0Jacksonville SunsGrayson Stadium22Columbus Astros9–0Savannah BravesGolden Park23Montgomery Rebels3–0Asheville OriolesPaterson Field24Jacksonville Suns3–0Birmingham A'sWolfson Park25Jacksonville Suns3–0 Columbus AstrosWolfson Park26Savannah Braves6–0 Birmingham A'sGrayson Stadium27Montgomery Rebels1–0 Jacksonville SunsPaterson Field28Jacksonville Suns3–0 Columbus AstrosGolden Park29Montgomery Rebels8–0 Charlotte O'sPaterson Field30Orlando Twins3–0Savannah BravesTinker Field31Columbus Astros3–0 Montgomery RebelsGolden Park32Memphis Chicks1–0 Montgomery RebelsTim McCarver Stadium33Jacksonville Suns4–0Nashville SoundsHerschel Greer Stadium34Savannah Braves0–1Jacksonville SunsWolfson Park35Jacksonville Suns6–0Knoxville Blue JaysWolfson Park36Columbus Astros2–0Nashville SoundsGolden Park37Nashville Sounds5–1 Columbus AstrosHerschel Greer Stadium38 Mercedes Esquer Tim Rodgers Knoxville Blue Jays0–1 Charlotte O'sJim Crockett Memorial Park39Knoxville Blue Jays2–0Memphis ChicksBill Meyer Stadium40Charlotte O's6–0Columbus AstrosGolden Park41Memphis Chicks16–0Columbus AstrosTim McCarver Stadium42Knoxville Blue Jays3–0 Charlotte KnightsBill Meyer Stadium43Jacksonville Expos1–0Orlando Sun RaysWolfson Park44Charlotte Knights4–0 Huntsville StarsJoe W. Davis Stadium45Knoxville Blue Jays2–0 Greenville BravesGreenville Municipal Stadium46Orlando Sun Rays2–0 Chattanooga LookoutsEngel Stadium47 Chris Howard John Hudek Birmingham Barons4–1Charlotte KnightsHoover Metropolitan Stadium48Orlando Sun Rays3–0 Knoxville Blue JaysBill Meyer Stadium49 Dennis Tafoya Carolina Mudcats1–0 Chattanooga LookoutsFive County Stadium50 Roger Smithberg Todd Revenig Huntsville Stars1–0 Birmingham BaronsHoover Metropolitan Stadium51Chattanooga Lookouts1–0 Birmingham BaronsHoover Metropolitan Stadium52Huntsville Stars5–0Chattanooga LookoutsEngel Stadium53Memphis Chicks3–0 Knoxville SmokiesTim McCarver Stadium54Greenville Braves2–0Knoxville SmokiesGreenville Municipal Stadium55Birmingham Barons1–0Memphis ChicksTim McCarver Stadium56 Memphis Chicks0–1 Chattanooga LookoutsEngel Stadium57Chattanooga Lookouts6–0Huntsville StarsJoe W. Davis Stadium58 Scott Simmons David Holdridge Memphis Chicks4–0Chattanooga LookoutsTim McCarver Stadium59 Memphis Chicks6–0 Carolina MudcatsFive County Stadium60West Tenn Diamond Jaxx1–0Jacksonville SunsPringles Park61Tennessee Smokies3–0 Orlando RaysSmokies Park62Jacksonville Suns1–0 Tennessee SmokiesWolfson Park63 Matt Beaumont Brian Tokarse Birmingham Barons5–0Tennessee SmokiesHoover Metropolitan Stadium64Orlando Rays2–0Tennessee SmokiesSmokies Park65 Steve Kent Ryan Baker Carolina Mudcats1–0 Mobile BayBearsFive County Stadium66Orlando Rays1–0 Jacksonville SunsWolfson Park67 Kevin Cave Carolina Mudcats5–0 Huntsville StarsJoe W. Davis Stadium68Carolina Mudcats2–0West Tenn Diamond JaxxPringles Park69 Jonthan Broxton Jacksonville Suns2–0Birmingham BaronsWolfson Park70Tennessee Smokies3–0 Huntsville StarsSmokies Park71 David Johnson Luis Pena Huntsville Stars5–0Tennessee SmokiesJoe W. Davis Stadium72Huntsville Stars2–0 Chattanooga LookoutsAT&T Field73Mississippi Braves6–0Birmingham BaronsTrustmark Park74Birmingham Barons3–0 West Tenn Diamond JaxxRegions Park75 Ty'Relle Harris Mississippi Braves2–0Mobile BayBearsTrustmark Park76Montgomery Biscuits8–0Mobile BayBearsHank Aaron Stadium77 Wilkin De La Rosa Pensacola Blue Wahoos6–0Mobile BayBearsPensacola Bayfront Stadium78 Dan Merklinger R.J. Seidel Darren Byrd Brandon Kintzler Huntsville Stars3–1Chattanooga LookoutsJoe W. Davis Stadium79Tennessee Smokies10–0Jacksonville SunsBaseball Grounds of Jacksonville80 Matt Gorgen Derek Eitel Willy Paredes Jake Barrett Mobile BayBears2–0Huntsville StarsJoe W. Davis Stadium81Montgomery Biscuits3–0Jacksonville SunsMontgomery Riverwalk Stadium82Chattanooga Lookouts1–0Tennessee SmokiesAT&T Field83Birmingham Barons2–0 Tennessee SmokiesSmokies Stadium84 Matt Magill Carlos Gonzalez Pensacola Blue Wahoos6–0 Jacksonville SunsBaseball Grounds of Jacksonville85 Jared Mortensen Jordan Harrison Kyle Winkler Montgomery Biscuits2–1Jackson GeneralsThe Ballpark at Jackson86Pensacola Blue Wahoos1–0Mobile BayBearsHank Aaron Stadium87 Forrest Snow Nick Ramirez Jorge López Biloxi Shuckers1–0 Tennessee SmokiesMGM Park88 Matt Custred Ryan Clark Mobile BayBears1–0Montgomery BiscuitsMontgomery Riverwalk Stadium89 Greg Mahle Adrian Almeida Ryan Clark Mobile BayBears9–0Birmingham BaronsHank Aaron Stadium90 Daniel Gibson Kirby Bellow Kevin Ginkel Brad Goldberg Jackson Generals6–0Jacksonville Jumbo ShrimpBaseball Grounds of Jacksonville91 Jeremy Walker Mississippi Braves2–0Jackson GeneralsTrustmark Park92 Zach Vennaro Nathan Kirby Matt Hardy Biloxi Shuckers1–0Mississippi BravesMGM Park93 Daysbel Hernández Mississippi Braves6–0Pensacola Blue WahoosTrustmark Park94 Danis Correa Eury Ramos Tennessee Smokies5–0Montgomery BiscuitsSmokies Stadium95 Samuel Reyes Bryan King Nicholas Padilla Tennessee Smokies2–0Rocket City Trash PandasSmokies Stadium96 Luke Murphy Eric Torres Rocket City Trash Pandas8–0Biloxi ShuckersToyota Field97 Ben Joyce Eric Torres Rocket City Trash Pandas5–7 Chattanooga LookoutsToyota Field98Sean Hunley Jeff Belge Enmanuel Mejia Graham Spraker Montgomery Biscuits10–0 Tennessee SmokiesMontgomery Riverwalk Stadium99Mississippi Braves2–0 Biloxi ShuckersTrustmark Park100 Garrett Schoenle Birmingham Barons1–0 Chattanooga LookoutsRegions Field101 A.J. Puckett Sam Armstrong Knoxville Smokies5–1 Columbus ClingstonesSynovus Park

No-hitters by team

Active Southern League teams appear in bold.

TeamNo-hittersPerfect gamesKnoxville Smokies (Knoxville Blue Jays/Tennessee Smokies) 11 0Birmingham Barons (Birmingham A's) 9 1Jacksonville Suns (Jacksonville Expos) 9 0Montgomery Rebels 8 1Columbus Astros (Columbus White Sox) 6 0Memphis Chicks 6 0Huntsville Stars 5 0Mississippi Braves 5 0Orlando Rays (Orlando Twins/Sun Rays) 5 1Carolina Mudcats 4 0Montgomery Biscuits 4 0Chattanooga Lookouts 3 0Mobile BayBears 3 0Pensacola Blue Wahoos 3 1Savannah Braves 3 0Charlotte Knights (Charlotte O's) 2 0Columbus Confederate Yankees 2 0Jackson Generals (West Tenn Diamond Jaxx) 2 0Asheville Tourists 2 0Biloxi Shuckers 2 0Rocket City Trash Pandas 2 0Charlotte Hornets 1 0Evansville White Sox 1 0Greenville Braves 1 0Macon Peaches 1 0Nashville Sounds 1 0Totals 101 4

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