De Cruz is a surname. Notable people with the surname include:
Andrea De Cruz (born 1974), Singaporean actress and psychologist Franco De Cruz (born 1946), Malaysian field hockey player Helen De Cruz (1978–2025), Belgian philosopher
See also Ileana D'Cruz (born 1986), Portuguese actress Peter de Cruz (born 1990), Swiss curler Simon Tensing de Cruz (born 1954), Singaporean diplomat De la Cruz, people with this surname