Kostitsyn (, ) is a surname of Slavic-language origin. Notable people with this surname include:
Andrei Kostitsyn (born 1985), Belarusian ice hockey player Alexander Kostitsyn (1904 - 1943), Soviet general Sergei Kostitsyn (born 1987), Belarusian ice hockey player Vladimir Kostitsyn (born 1945), Russian geophysicist