ACEA-1328 is an NMDA receptor antagonist.
Pharmacodynamics ACEA-1328 acts as an antagonist of the glycine site at the NMDA receptor.
Effects
Opioid tolerance A study on mice has shown that ACEA-1328 was able to increase the analgesic action of morphine. It was also shown that it can reduce the formation of tolerance to morphine.
Cocaine overdose ACEA-1328 (along with other drugs) has been shown to be able to reduce convulsions induced by a cocaine overdose.
References