The 1922 Whitman Fighting Missionaries football team represented Whitman College as a member of the Northwest Conference during the 1922 college football season. Under seventh-year head coach Vincent Borleske, the Fighting Missionaries compiled an overall record of 2–4–1 with a mark of 2–2 in conference play, and finished third in the Northwest Conference. Whitman played home games at Ankeny Field in Walla Walla, Washington.

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