Mduduzi is a South African given name. Notable people with the name include:
Mduduzi Mdantsane (born 1994), South African soccer player Mduduzi Manana (born 1984), South African politician Mduduzi Mabaso (born 1975), South African actor Mduduzi Fuzwayo (1986–2023), Zimbabwean cricketer Mduduzi Shabalala (born 2004), South African soccer player Mduduzi Bacede Mabuza, Swazi politician and pro-democracy activist
See also Vincent Mduduzi Zungu (born 1966), South African Bishop of the Roman Catholic Church