Mncube is a South African surname. Notable people with the surname include:
Busisiwe Mncube, South African politician Ntando Mncube (born 1986), South African actor, singer, and dancer Themba Mncube, the professional name of Brian Ntuli (born 1991), South African filmmaker and actor Vusimuzi Mncube (born 1993), South African soccer player Wiseman Mncube (born 1990), South African actor, playwright, singer, and director
See also Nomusa Dube-Ncube, South African politician and diplomat