Papavasiliou or Papavasileiou () is a Greek surname. Notable people with the surname include:
Georgina Papavasiliou (born 1981), Scottish figure skater of Greek descent Georgios Papavasileiou (1930–2020), Greek middle-distance and steeplechase runner Nikodimos Papavasiliou (born 1970), Cypriot football player and manager Nina Papavasiliou, Greek immunologist Sakis Papavasiliou (born 1976), Greek football player and manager Vasilis Papavasileiou (1949–2025), Greek theatre director, actor, writer and translator