Fakhr al-Din Isa ibn Ibrahim al-Nasrani ("the Christian") (died 1303) was an Arab Christian who was a governor of the city of Mosul for the Mongol Ilkhanid ruler Ghazan Khan (r. 1295-1304). He was a bibliophile and was famous for his cultural activity, welcomed men of letters and poets at his residence.

He may have converted to Islam.

He was likely depicted in a frontispiece of Bal'ami's Persian version of Tabari's Universal History (F1957.16), enthroned and holding a hawk in his hand, a symbol of Mongol authority.

He was executed by Ghazan in 1303, following complaints of oppression and injustice by the inhabitants of Mosul.

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