Samuel Henderson may refer to:
Samuel Henderson (Pennsylvania politician) (1764–1841), member of the U.S. House of Representatives from Pennsylvania Samuel Henderson (Indianapolis mayor) (c. 1800–1883), first mayor of Indianapolis, Indiana Samuel Henderson (born 1827) (c. 1827–1907), African-American groundskeeper and Catholic convert, under consideration for beatification Sam Henderson (footballer), English footballer
See also Sam Henderson (born 1969), American cartoonist, writer, and expert on American comedy history