Spina is a surname which originated in Italy. The surname translates to "Thorn" and "Thorn bush" in italian. Notable people with the surname include:

Agostino Spina (born 2001), Argentine footballer Alessandro Spina (1927–2013), the pen name of Basili Shafik Khouzam, Italian-Syrian writer Alphonso de Spina (died 491), Spanish Franciscan Catholic Bishop Angelo Spina (born 1954), Italian Roman Catholic prelate Ashley Spina (born 1992), Australian soccer player Ben Spina (born 1988), Australian rugby league footballer Dave Spina (born 1983), American ice hockey player Francis X. Spina (born 1946), American judge Franz Spina (1868–1938), German-Czechoslovak politician Gerónimo Spina (born 2005), Argentine footballer Harold Spina (1906–1997), American composer Joanie Spina (1953–2014), American dancer, choreographer, magician and director Joe Spina (born 1946), Canadian politician Joey Spina (born 1977), American boxer Juan-Francisco Spina (born 1985), Argentine tennis player Lane Spina (born 1962 or 1963), American freestyle skier Laurie Spina (born 1963), Australian rugby league footballer and commentator Maria Grazia Spina (1936–2025), Italian actress Marcelo Spina (born 1970), Argentine architect Scipione Spina (died 1639), Italian Roman Catholic Bishop

See also Spina (disambiguation)