Senén is a Spanish male given name. Notable people referred to by this name include the following:
Senén Mosquera (1938–2018), Colombian footballer Senén Casas Regueiro (1934–1996), Cuban politician Senén Villaverde (1896–1950), Spanish footballer Senen Reyes (born 1965), Cuban-American rapper
See also Senen, Senen, an administrative village in the Senen district of Indonesia