Ayoola is a given name and a surname. Notable people with the name include:
First name Ayoola Adeleke (born 1923), Nigerian politician, labour activist, and senator Ayoola Ayolola (born 1987), Nigerian musician, singer, and actor Ayoola Erinle (born 1980), England international rugby union player Ayoola Smart (born 1994), Irish actress
Middle name Moses Adeshina Ayoola Junior Odubajo (born 1993), English professional footballer Ayo Ayoola-Amale, Nigerian poet and layer
Surname Adejoke Ayoola (born 1970), Nigerian-American academic Emmanuel Ayoola (1933–2024), Nigerian lawyer and judge Gbolahan Ayoola (born 1977), Nigerian-based painter