Grullón is a surname. Notable people with the surname include:
Alejandro Grullón (1929–2020), Dominican banker and businessman Arturo Grullón (1869–1942), Dominican painter, ophthalmologist, and educator Deivy Grullón (born 1996), Dominican baseball catcher Juan Isidro Jimenes Grullón (1903–1983), Dominican essayist, historian, physician, philosopher, educator, and politician Manuel Alejandro Grullón (born 1953), Dominican businessman