Sysuyev () is a Russian surname. The feminine form is Sysuyevа (). Among those with this name are:
Dmitri Sysuyev (born 1988), Russian footballer Nikolai Sysuyev (born 1999), Russian footballer Vladislav Sysuyev (born 1989), Russian footballer Yegor Sysuyev (born 1997), Russian footballer Yuri Sysuyev (born 1949), Russian naval officer