Ruymbeke is a Belgian surname. Notable people with the surname include:
Douglas De Ruymbeke (1894–1977), Belgian footballer, brother of Paul, Joseph, and Gaston (1900–1928), Belgian footballer, brother of Douglas, Paul, and Gaston Bobby De Ruymbeke (1898–1963), Belgian footballer, brother of Douglas, Joseph, and Gaston (1921–2012), resistance fighter, senior civil servant, and French business leader Renaud Van Ruymbeke (1952–2024), French magistrate (born 1962), French historian (1903–1992), Belgian footballer, brother of Douglas, Bobby, and Joseph