Massagué is a Catalan-language surname. Notable people with the surname include:
Domingo Massagué (1900–1979), Spanish footballer Iván Massagué (born 1976), Spanish actor Joan Massagué (born 1953), Spanish biologist
See also Benito Messeguer (1930–1982), Mexican mural artist Conrado Walter Massaguer (1889–1965), Cuban artist, satirist and magazine publisher Maurice Mességué (1921–2017), French herbalist Soufiane Messeguem (born 2001), German footballer Yudelmis Domínguez Masague (born 1985), Cuban racing cyclist Massaguel, a French commune in Tarn Massaguet, a Chadian city in Hadjer-Lamis Merseguera, a Spanish grape variety