Macaya is a Spanish surname. Notable people with the surname include:
Alfonso Macaya (1878–1950), Spanish football executive and businessman Camila Macaya (born 1990), Chilean badminton player Enrique Macaya Márquez (born 1934), Argentine sports journalist Ignacio Macaya (1933–2006), Spanish field hockey player Javier Macaya (born 1978), Chilean lawyer and politician Román Macaya, Costa Rican scientist, entrepreneur, diplomat, and public servant