d'Affry is a surname of a noble family, the , of the Swiss canton of Fribourg. It may refer to:
Adèle d'Affry (1836–1879), Swiss artist and sculptor (1772–1818), Swiss colonel (1667–1734), Swiss lieutenant general Louis-Auguste-Augustin d'Affry (1713–1793), Swiss military officer and diplomat (1743–1810), Swiss field marshal and diplomat