Cayuela is a Spanish surname. Notable people with the surname include:
Antonio Cayuela (1917–2006), Spanish footballer Aquilino Cayuela (born 1967), Spanish writer, columnist, and professor (1907–1993), Spanish painter and draftsman (born 1944), Spanish footballer , Spanish sailor Pepe Cayuela (born 1950), Spanish football manager (1919–1993), Spanish painter and sculptor
See also Cayuela, a municipality located in the province of Burgos, Castile and León, Spain