Manzanedo is a Spanish surname. Notable people with the surname include:
People Alfonso Manzanedo de Quiñones (1552–1627), Roman Catholic prelate Gómez González de Manzanedo (–1182), Castilian magnate José Luis Manzanedo (born 1956), Spanish footballer Juan Manzanedo (1898–?), Spanish footballer Laura Manzanedo (born 1976), Spanish actress and presenter of radio
See also Valle de Manzanedo, a municipality located in the province of Burgos