Tiflucarbine (BAY-P 4495 or TVX P 4495) is an experimental drug which acts as an agonist of the 5-HT1 and 5-HT2 serotonin receptor families, and also acts as a calmodulin inhibitor. It has antidepressant effects in animal studies. It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.Glaser, T., Dompert, W. U., Horvath, E., Schuurman, T., Spencer, D. G., & Traber, J. (1987, November). Tiflucarbine, a potential new antidepressant: Biochemical and behavioral pharmacology. In Abstract P22, International Conference on the Behavioral Pharmacology of Serotonin. https://scholar.google.com/scholar?cluster=15335975313192901460 In addition, it partially substituted for DOM and 8-OH-DPAT in rodent drug discrimination tests, with further generalization but concomitant substantial behavioral disruption in 5-MeO-DMT-trained rodents. Tiflucarbine is similar in structure to but distinct from β-carbolines, instead being a γ-carboline.
See also List of miscellaneous serotonin 5-HT2A receptor agonists Substituted γ-carboline 2MePI
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