HOT-x, also known as 4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines or hydroxylated 2C-T derivatives, are a group of psychedelic drugs of the phenethylamine and 2C families. They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring. The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs.
The HOT-x drugs were synthesized and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).
Use and effects
+ Compound Chemical name Dose Duration HOT-2 (N-hydroxy-2C-T-2) N-Hydroxy-4-ethylthio-2,5-dimethoxyphenethylamine 10–18 mg 6–10 hours HOT-7 (N-hydroxy-2C-T-7) N-Hydroxy-4-propylthio-2,5-dimethoxyphenethylamine 15–25 mg 6–8 hours HOT-17 (N-hydroxy-2C-T-17) N-Hydroxy-4-sec-butylthio-2,5-dimethoxyphenethylamine 70–120 mg 12–18 hours Refs:
All three of the HOT-x drugs produce psychedelic effects according to Shulgin. The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act as prodrugs to these compounds.
Interactions
Society and culture Legal status Canada The HOT-x drugs are controlled substances in Canada under phenethylamine blanket-ban language.
See also 2C (psychedelics) Substituted methoxyphenethylamine N-Hydroxyamphetamine MDOH (MDH; N-OH-MDA) MDHMA (FLEA; N-OH-MDMA) 2C-B-OH (N-hydroxy-2C-B) N-Hydroxy-DOM N-Hydroxy-AMT
References
External links #87 HOT-2 - PiHKAL - Erowid #88 HOT-7 - PiHKAL - Erowid #89 HOT-17 - PiHKAL - Erowid