Rose O'Neill (1874–1944) was an American cartoonist and writer.
Rose O'Neill may also refer to:
Rose O'Neill (Irish noblewoman) (fl. 1587–1607), Gaelic Irish noblewoman and queen consort of Tyrconnell Rosa O'Neill (born Rosa O'Doherty; died 1660), Gaelic Irish noblewoman
See also Rose O'Neal Greenhow (1813–1864), American socialite and Confederate spy