[La] Serenissima ([The] Most Serene) may refer to:

Certain countries , a name for the Republic of Venice , the official Latin name of the Polish–Lithuanian Commonwealth

Art, entertainment, and media La Serenissima (musical ensemble), a British early music/period instrument ensemble La Serenissima (album), a 1981 album by Rondò Veneziano, also released as Venice in Peril "La Serenissima", a single by Rondò Veneziano, later covered by DNA and by Mike Candys "La Serenissima", an instrumental track from Loreena McKennitt's release, The Book of Secrets (1997) "Serenissima", a 1996 board game about 14th century Mediterranean commerce by Eurogames (game publisher)

Sport Scuderia Serenissima, an auto racing team La Serenissima, a nickname for the San Marino national football team

Other uses La Serenísima, an Argentine dairy products maker

Autostrada A4 (Italy), nicknamed Serenissima after its destination, Venice

See also Most Serene Republic