José Luis Espinosa may refer to:
José Luis Espinosa (footballer) (1913–1975), Spanish football goalkeeper and manager José Luis Espinosa (boxer) (born 1941), Mexican boxer José Luis Espinosa Piña (born 1968), Mexican politician José Luis Espinosa Arroyo (born 1991), known as Tiri', Spanish football centre-back
See also José Espinosa (disambiguation) José Espinoza (disambiguation)