10,11-Secoergoline, also known as 3-(2-piperidylmethyl)indole or as α,N-tetramethylenetryptamine, is the structure of ergoline in which the bond between the 10 and 11 positions of the ring system has been broken to unconstrain the molecule. It is also a tryptamine with the amine cyclized into a piperidine ring connected to the α position.
A notable derivative of 10,11-secoergoline is CT-5252 (methyl-12-bromo-8,9-didehydro-2,3β-dihydro-6-methyl-10,11-secoergoline-8-carboxylate), which is an analogue of lysergic acid diethylamide (LSD) with some of the same behavioral effects in animals but with much lower potency.
Another notable derivative is 10,11-seco-LSD (UCD0121).
See also Partial ergoline Secoergoline Seco-LSD Pyr-T (N,N-tetramethylenetryptamine) SN-22 (3-(1-methyl-4-piperidinyl)indole) MPMI (3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole) RU-24,969 EMD-386088 Mefloquine
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