5-Allyloxy-AMT, also known as 5-allyloxy-α-methyltryptamine, is a serotonin 5-HT2 receptor agonist of the tryptamine, 5-alkyloxytryptamine, and α-alkyltryptamine families.
It is known to act as high-efficacy partial agonist or near-full agonist of the serotonin 5-HT2A receptor ( = 162nM; = 89%) and of the serotonin 5-HT2B receptor ( = 60nM; = 82%), whereas activity at the serotonin 5-HT2C receptor and other serotonin receptors was not reported.
5-Allyloxy-AMT was the most potent serotonin 5-HT2A receptor agonist reported in a large series of tryptamines that was evaluated in search of potent and selective serotonin 5-HT2B receptor agonists. The only exceptions were the reference serotonin 5-HT2A receptor agonists serotonin (5-HO-T) ( = 79nM; = 100%) and (S)-α-methylserotonin ((S)-αMS) ( = 54nM; = 103%).
See also Substituted tryptamine 5-Ethoxy-AMT 5-Ethoxy-DMT 5-Methoxy-AMT 5-(Nonyloxy)tryptamine 5-Benzyloxytryptamine BW-723C86
References
External links 5-Allyloxy-AMT - Isomer Design