Macazaga is a Basque language surname. Notable people with the surname include:
Lucas Macazaga (born 2006), Spanish-Bolivian footballer Xabier Mancisidor (born 1970, full name Xabier Macisidor Macazaga, Spanish footballer and coach Francisco Javier Macazaga Azurmendi, assassin of Spanish politician Manuel Indiano Azaustre in 2000