3-Hydroxy-N,N-dimethylphenethylamine (developmental code name LSM-6) is a drug of the phenethylamine family which was under development for the treatment of mood disorders but was never marketed. It is the N,N-dimethylated derivative of meta-tyramine (3-hydroxyphenethylamine). The drug is a naturally occurring constituent of Limacia plants and is described as an adrenergic and serotonergic agent. It may act as a monoamine releasing agent and/or reuptake inhibitor. LSM-6 has sympathomimetic effects. It was being developed in the 1990s in Malaysia. The drug reached the preclinical research stage of development prior to its discontinuation.
See also List of investigational antidepressants Trichocereine (3,4,5-trimethoxy-N,N-dimethylphenethylamine) Macromerine (β-hydroxy-3,4-dimethoxy-N,N-dimethylphenethylamine) Dimethylamphetamine (N,N-dimethylamphetamine) Gepefrine (3-hydroxyamphetamine) Pholedrine (4-hydroxy-N-methylamphetamine) 4-Hydroxyamphetamine (norpholedrine)
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