Vuyisile is a given name, derived from the Nguni word vuya, meaning "be happy". Notable people with the given name include:
Vuyisile Colossa (born 1982), South African boxer Vuyisile Malomane, South African politician Thembeka Vuyisile Buyisile Mchunu (born 1968), South African politician Vuyisile Mini (1920–1964), South African trade unionist Vuyisile Wana (born 1987), South African soccer player