Derakhshani is a surname. Notable people with the surname include:
Ali Akbar Derakhshani (1896–1978), Iranian army officer Borna Derakhshani (born 2002), Iranian chess player Dorsa Derakhshani (born 1998), Iranian-American chess player Majid Derakhshani (born 1957), Iranian musician and composer Reza Derakhshani, computer scientist and electrical engineer