Derome or DeRome is a surname. Notable people with the surname include:
Albert Thomas DeRome (1885–1959), American artist Bernard Derome (born 1944), Canadian broadcaster Jean Derome (born 1955), Canadian saxophonist, flautist, and composer Julie-Anne Derome, Canadian violinist Philippe Derome (born 1937), French figurative painter Wilfrid Derome (1877–1931), American forensic scientist