D'Mello is a surname. Notable people with the name include:
Ambrose D'Mello (1922–2010), Indian Jesuit priest Beevan D'Mello (born 1987), Indian footballer Dave D'Mello (born 1970), British dance music DJ and record producer Milton D'Mello (born 1925), Pakistani field hockey player Placid D'Mello (1919–1958), Indian trade union leader Raymond D'Mello, 20th-century Roman Catholic bishop in India Rockie D'Mello (born 1961), Indian-born Kenyan cricket umpire Suzanne D'Mello, Indian playback singer of Bollywood films William Leonard D'Mello (1931–2011), Roman Catholic bishop of the Diocese of Karwar, India
See also 30272 D'Mello, minor planet, 3.9 km diameter D'Mello House, abandoned mansion built during the Portuguese rule in Goa, in Santimol, Raia P D'Mello Road, 6 km long arterial north–south access road in Mumbai