Crespin is a surname. A Spanish variant of the name is Crespín. Notable people with the surname include:
Augusto Crespin (born 1956), Salvadoran artist Elias Crespin (born 1965), Venezuelan kinetic artist Irene Crespin (1896–1980), Australian geologist and micropalaeontologist Jean Crespin (c. 1520–1572), French Protestant lawyer and printer Marie-José Crespin (1936–2025), Senegalese magistrate Rafaela Crespín Rubio (born 1976), Spanish politician Régine Crespin (1927–2007), French soprano Renée Crespin du Bec (died 1659), Countess de Gebriand, the first female ambassador in the history of France
See also Crespin Carlier (c. 1560–1636), French organ builder Joe Benny Corona Crespín, known as Joe Corona (born 1990), American soccer player Crispin (surname), people with this surname