Mary Barker may refer to:
Mary Cornelia Barker (1879–1963), American educator and labor activist Mary Anne Barker (1831–1911), English author Mary Ross Barker (1905–2004), Canadian educator Mary Jane Barker (1953–1957), American girl who died from starvation, see death of Mary Jane Barker Mary Barker Bates (1845–1924), née Barker, American physician and surgeon