The substituted naphthylethylamines are a class of chemical compounds based on naphthalene. Many naphthylethylamines are naphthylaminopropanes (also known as naphthylisopropylamines) due to the presence of a methyl group at the alpha carbon of the alkyl chain. The naphthylethylamines are derivatives of the phenethylamines, while the naphthylaminopropanes are derivatives of the amphetamines.
There are two types of naphthylethylamines based on positional isomerism: 1-naphthylethylamines and 2-naphthylethylamines. Examples of these include 1-naphthylaminopropane (1-NAP) and 2-naphthylaminopropane (2-NAP), respectively.
List of substituted naphthylethylamines The substituted napthylethylamines include the following compounds:
Additional naphthylethylamines include 4-NEMD, centanafadine (EB-1020), nafimidone, naphazoline, and xaliproden (SR-57746). Some synthetic cannabinoids such as THJ-018 and THJ-2201 are also naphthylethylamines.
Related compounds Some related compounds that are not technically naphthylethylamines include 1-naphthylpiperazine and its derivatives like CSP-2503, F-11,461, S-14506, and S-14671. Another related compound is 2-naphthylpiperazine. DMNPC is a 2-naphthylpiperidine.
Pharmacology Many naphthylethylamines, like 2-naphthylaminopropane and derivatives, act as monoamine releasing agents (MRAs), monoamine reuptake inhibitors (MRIs), and/or monoamine receptor modulators. Naphthylpropylaminopentane (NPAP) is a monoaminergic activity enhancer (MAE). Some, such as 2-naphthylaminopropane and to a lesser extent 1-naphthylaminopropane, but not others, such as NPAP, are also variably potent monoamine oxidase inhibitors (MAOIs).
+ Compound Ref d-Amphetamine 6.6–10.2 5.8–24.8 698–1,765 1-Naphthylaminopropane 2-Naphthylaminopropane (NAP; PAL-287) 11.1 12.6 3.4 d-Methamphetamine 12.3–14.3 8.5–40.4 736–1,292 Methylnaphthylaminopropane (MNAP; PAL-1046) 34 10 13 l-Methcathinone 13.1 14.8 1,772 1-Naphthylmethcathinone (AMAPN) 92% at 10μM 55 21 2-Naphthylmethcathinone (BMAPN; βk-MNAP) 94% at 10μM 34 27 d-Ethylamphetamine 28.8 44.1 333.0 Ethylnaphthylaminopropane (ENAP; PAL-1045) 137 46 a 12 a 2-Phenylmorpholine (PAL-632) 79 86 20,260 Naphthylmorpholine (PAL-678) Phenmetrazine 29–50.4 70–131 7,765–>10,000 Naphthylmetrazine (PAL-704) 203 111 (105) Notes: The smaller the value, the more strongly the drug releases the neurotransmitter. The assays were done in rat brain synaptosomes and human potencies may be different. See also Monoamine releasing agent § Activity profiles for a larger table with more compounds. Footnotes: a is a partial releaser of serotonin ( = 66%) and dopamine ( = 78%). Refs:
See also Substituted phenethylamine Substituted amphetamine Substituted cathinone Substituted methylenedioxyphenethylamine Substituted benzofuran Substituted 2-aminoindane Substituted tryptamine
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