Zisis () is both a Greek masculine given name and a surname. Notable people with the name include:
Given name Zisis Babanasis (born 1964), Greek fencer Zisis Chatzistravos (born 1999), Greek footballer Zisis Karachalios (born 1996), Greek footballer Zisis Karademos (died 1705), Greek armatole Zisis Oikonomou (1911–2005), Greek poet and prose writer Zisis Sarikopoulos (born 1990), Greek basketball player Zisis Sotiriou (born early 1800s), Greek revolutionary of the Greek War of Independence Zisis Tsekos (born 1964), Greek footballer Zisis Verros (1880–1985), Greek chieftain of the Macedonian Struggle Zisis Vrakas (born 1857), Greek chieftain of the Macedonian Struggle Zisis Vryzas (born 1973), Greek footballer and technical director Zisis Ziagas (born 1972), Greek footballer
Surname Georgios Zisis (born 1999), Greek footballer Ioannis Zisis (1881–1941), Hellenic Army General during World War II Nikos Zisis (born 1983), Greek basketball executive and former basketball player