The Mainichi Film Award for Best Lead Performance is a film award given at the Mainichi Film Awards. In 2024, the Mainichi Film Awards announced that the four acting categories would be retired and replaced with two gender neutral categories, with both Best Male Lead and Best Female Lead merging into the Best Lead Performance category.

Award winners Year Actor Film2024 Yuumi KawaiA Girl Named AnnDesert of Namibia Ryusei YokohamaFaceless 2025 Ryo YoshizawaKokuho

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